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Metformin also stimulates AMPK, which activates mitochondrial synthesis and FA -oxidation, which are important for maintaining and promoting mitochondrial function [170]

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Emerged in the 1990s as a way to reinterpret the evolving interplay between cities and their surrounding regions, the concept of 'functional areas' may be useful in this concern, indicating a shift in spatial governance and planning dynamics towards models pivoted around rigid, matryoshka-style administrative units towards more flexible, place-based approaches aimed at meeting actual territorial needs (Barca, 2009