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Sulfapyridine significantly enhances the cytotoxicity of daunorubicin-cytarabine to leukemia cells, as confirmed in patient-derived xenograft models

Damage to mitochondria resulting from iron overload leads to a reduction in ATP synthesis, which may impair cardiac contractility [66, 67]

reported that the process of iron-mediated ROS production promoted the process of M1 macrophage polarization by increasing the p300/CBP acetyltransferase activity and facilitating the process of p53 acetylation (Zhou et al., 2018)

Consequently, according to NCCN guidelines, HER2-targeted therapy is now recommended as subsequent therapy options for RAS wild-type, BRAF wild-type, and HER2 amplified CRC patients [14, 26]