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There is currently no strong scientific evidence demonstrating that Mecobalamin or Vitamin B12 injections directly cause weight gain

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Medications that interact with B12 in some way include: Aminosalicylic acid, a drug used to treat digestive problems Chloramphenicol, an antibiotic for bacterial infections such as conjunctivitis and meningitis Colchicine, an anti-inflammatory drug used to treat gout Histamine H2 receptor antagonists, such as cimetidine, famotidine, and ranitidine, for peptic ulcers Metformin, a diabetes medication Proton pump inhibitors, to reduce stomach acid (such as omeprazole and lansoprazole), which can reduce B12 absorption Also, vitamin C (ascorbic acid) supplements can reduce the amount of B12 available

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