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doi: 10.1016/S0076-6879(01)35230-8 584 GuLKelmMAHammerstoneJFBeecherGHoldenJHaytowitzDet al

Mitogen-activated protein kinases (MAPKs) are serine and threonine protein kinases that are highly conserved in eukaryotes, and are involved in signal transduction pathways that modulate physiological and pathophysiological cell responses