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The CLAGs are predicted to harbor a region that may form a transmembrane domain that is lined with polar residues on one side and non-polar on the other, reminiscent of the domains that form water-filled pores ( A soluble form of RhopH protein complex structure has recently been solved via cryoelectron microscopy ( C -terminus, is buried in the core of the RhopH complex and is not exposed to solvent