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Tumor-associated macrophages as a potential therapeutic target in thyroid cancers

PLA2G6 PLA2G6 encodes calcium-independent phospholipase A2 protein (iPLA2), an enzyme that selectively hydrolyzes glycerophospholipids and participates in diverse cellular functions including mitochondrial function, release of lipid mediators, cell growth, apoptosis, and calcium signaling ( PLA2G6 is associated with neurodegenerative disorders in humans, such as autosomal recessive neuroaxonal dystrophy and early-onset parkinsonism in humans ( PLA2G6 knockout mice, ultra-structurally abnormal mitochondria with the inner membrane degeneration were reported in spinal cord neurons ( iPLA2-VIA gene in Drosophila (Drosophila homolog of PLA2G6 ) caused locomotor deficits and mitochondrial abnormalities, including defective morphology, decreased production of ATP, and mitochondrial respiratory chain dysfunction ( PLA2G6 was confirmed to be closely associated with elevated mitochondrial lipid peroxidation ( PLA2G6 leads to membrane remodeling and mitochondrial dysfunction

The truncated form of NK-1R binds substance P with 10-fold lower affinity than the long form (Douglas and Leeman, 2011)

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