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In addition to these treatments, many patients benefit from a comprehensive rehabilitation program that includes strengthening exercises, flexibility training, and education on proper body mechanics

The Phase 2 trial data showed nausea in roughly 28% of patients at the 12mg dose, diarrhea in 24%, vomiting in 17%, and constipation in 11%

Kovalzon and Strekalova, summarizing the field in 2006, were explicit: the link between DSIP and sleep had never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor, and the hypothesis of DSIP as a sleep factor was extremely poorly documented and still weak (Kovalzon & Strekalova, 2006)

But the jump from 10 mg to 15 mg is much smaller: 21.4% to 22.5%