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Moreover, in the bio portal TGCA AML cohort, overexpression of both GPX1 and GPX4 which is found in a significant subset of patients is associated with a poor prognosis [36]

Lane 4, Purified His-tagged protein (27 kDa) using Ni-charged MagBeads

Toubal A, Kiaf B, Beaudoin L, Cagninacci L, Rhimi M, Fruchet B, da Silva J, Corbett AJ, Simoni Y, Lantz O, Rossjohn J, McCluskey J, Lesnik P, Maguin E, Lehuen A (2020) Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

The gastrointestinal tract plays a key role in Mn uptake, mediated by metal transporters, and these transporters can also contribute to Mn excretion via the gastrointestinal tract and the hepatobiliary system (Mercadante et al., 2019