bpc-157 safety efficacy research for athletes and injury treatment: Science, safety, and legal concerns The Hidden Risks of BPC‑157:

Because of the long elimination half-lives of the parent drug and its major active metabolite, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment

Conclusions Vitamin B 12 deficiency and its associated etiological factors should be considered in patients with glossodynia, even those whose oral mucosa appears normal and who lack a history of gastrectomy

Ehses, S

Increases in TER reflect a tightening of the paracellular pathway and enhanced barrier function, whereas decreases indicate TJ barrier compromise (Moyes et al., 2007)