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doi: 10.1021/jm070037v

For example, berberine was found to inhibit cardiac fibroblast proliferation and myofibroblast differentiation by modulating AMPK/PGC-1 signaling, helping to alleviate cardiac fibrosis in models of ischemic or diabetic cardiomyopathy (Hu et al., 2025)

Following repeated antigenic stimulation, high expression of PD-1 and other co-inhibitory molecules has been identified as an indicator of T-cell exhaustion and dysfunction, particularly in cells isolated from the tumor microenvironment (63)