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Some are directly involved in mitochondrial functions, such as PRKN, PINK1 , and DJ-1

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Clin Nephrol 56:7577 Yoshida H, Akikusa B, Saeki N, Hasegawa S, Iesato K, Yamamoto S, Murotani N, Wakashin M, Shimada T (1999) Effect of pituitary microsurgery on acromegaly complicated nephrotic syndrome with focal segmental glomerulosclerosis: Report of a rare clinical case

Research shows that changes in estrogen levels and activation of neurokinin 3 receptors in the hypothalamus are involved in triggering hot flashes