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Our study demonstrated that Gln deprivation severely inhibited the tumor growth of HCC and PCa both in vivo and in vitro, and this occurs partially through reduced GSH levels, resulting in ROS accumulation

Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus

Notably, mutation of E 115 inactivates CHAC1, preventing GSH depletion in vivo ( The molecular mechanism of -glutamyl amino acid degradation by GCT family enzymes is well understood