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Preliminary findings from these studies suggest a tolerable oral dosage of approximately 100mg/kg in mice [1]

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Biological Evaluation of Medical DevicesPart 4: Selection of Tests for Interactions with Blood

Lithium, a mood stabilizer widely used in bipolar disorder, is a potent inhibitor of GSK3 and has been shown to enhance the efficacy of some other antidepressants in MDD (152)