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Antioxidants and free radical scavengers, including Vitamins C and E and N-acetylcysteine, have been evaluated

Individuals with advanced alcoholism frequently present with clinical liver disease while reporting low perceived intoxication levels, precisely because neuroadaptive tolerance has altered CNS GABA-ergic and noradrenergic baseline signaling

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Age-related physiological changes, including reduced hepatic and renal function, could lead to elevated plasma concentrations of S-CIT in older patients, increasing their susceptibility to adverse drug reactions (Rao, 2007)