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Cortes and La Spada 2014)

Activity outside the known reactions of the metabolic model, such as the NAD/NADH ratio, are not considered

Unlike most of the rest of the US, Arizona has had unusually rapid population growth over the last several decades, from 2.7 million in the 1970 census to an estimated 6.1 million in 2006

Consistent with our conjecture, the declining levels of GSR activity and GSH with consequent impaired the capacity of defense against oxidative stress in the combination group, allowing for the increased ROS and accumulation of MDA and 4-HNE