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10.1136/bjophthalmol-2016-309814 133

Acknowledgments We are grateful to the Research Center of Clinical Epidemiology (Peking University Third Hospital, China) for supporting our study

This pattern, sometimes called HPA axis dysfunction, is what many people mean when they refer to adrenal fatigue

However, ICIs have shown limited efficacy in treating PDAC, predominantly because of the hostile TME characterized by fibrosis, hypoxia, and immunosuppression [148]