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Several in vitro and in vivo studies provided evidence demonstrating the nootropic and neuroprotective effects displayed by erinacines

Asct2 overexpression is associated with poor survival of oscc patients and Asct2 knockdown inhibited growth of glutamine-addicted oscc cells

The C5aC5aR interaction on trophoblast cells polarizes them toward an anti-angiogenic phenotype by balancing their angiogenic factors, such as sFlt1 or soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and PIGF (410, 413)