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For individuals living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), the relationship with Vitamin B12 is often complicated by underlying genetics

10.3389/fimmu.2022.845684 [DOI] [PMC free article] [PubMed] [Google Scholar] 153.Wei, J

The proposed mechanism involves NNMT inhibition increasing the SAM:SAH ratio and NAD+ precursor availability, activating sirtuin-mediated metabolic programs