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Notably, at 6 M, curcumin synergistically reduces interleukin-1(IL-1)/IL-6 secretion by 50% through inhibition of extracellular signal-regulated kinases/c-Jun N-terminal kinases (ERK/JNK) phosphorylation (EC50 = 8.4 M) and targeting of the signal transducer and activator of transcription 3 src homology 2 (STAT3 SH2) domain (G = 7.1 kcal/mol) (Peng et al., 2021

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doi: 10.1038/s41392-023-01720-0 186 HuangMTengQCaoFHuangJPangJ

Some risk factors such as biopsychosocial characteristics, clinical features of the current depressive episode, and physical and mental comorbidities can have an impact on response to pharmacologic treatments