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The efficacy of this therapeutic combination was first validated in our breast cancer models, demonstrating that PHGDH wild type breast cancer cells do not respond to the therapeutic combination, whereas PHGDH-amplified breast cancer cells exhibited a synergistic sensitivity to suboptimal dosages of sertraline plus chloroquine (Figure S8A)

Appropriate sterile techniques must be followed, e.g., cleaning the injection site with an alcohol wipe thoroughly prior to the injection

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