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It is important to note that the stimulation of GSK3 leads to phosphorylation of insulin receptor substrate protein 1 (IRS1) affecting insulin like growth factor 1 signaling (IGF-1) and resulting in downstream insulin resistance (Leng et al., 2010

2 AmmarA.TurkiM.ChtourouH.HammoudaO.TrabelsiK.KallelC.et al (2016)

The linkers used for constructing ncAA incorporated bispecific nanobodies were heterobifunctional chemical crosslinkers BCN (Bicyclononyne, MW 401.2287) and Tet (Tetrazine, MW 387.1), which were obtained from commercial sources and used without further purification