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Figure 1: Kaplan-Meier Curve for Overall Survival in KEYNOTE-189* *Based on the protocol-specified final OS analysis Initial Treatment in Combination with Cisplatin The efficacy of pemetrexed for injection was evaluated in Study JMDB (NCT00087711), a multi-center, randomized (1:1), open-label study conducted in 1725 chemotherapy-naive patients with Stage IIIb/IV NSCLC

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Western blotting analysis further confirmed that CM#3 upregulated cartilage-protective markers (AGG, COL2 and SOX9) while suppressing the expressions of catabolic markers (MMP3 and MMP13) and inflammatory markers (COX2 and iNOS) compared to CM#2 (Fig