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The contrasting responses to combined mTORC1 inhibition and ferroptosis induction in different cellular contexts are likely dictated by complex factors including genetic mutation landscape, the ratio of polyunsaturated to monounsaturated phospholipids, iron availability, the basal activities of the PI3K/mTORC1 pathway, and the overall cellular redox state

Chiang P K, Gordon R K, Tal J, Zeng G C, Doctor B P, Pardhasaradhi K, McCann P P, S-Adenosylmethionine and methylation, FASEB Journal

Koppenol, W

Mitochondrial-targeted antioxidants: Mitochondria are a major source of ROS, and mitochondrial dysfunction plays a critical role in oxidative stress and BBB disruption (Bhat et al., 2015)