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3.4 Long-term persistence of active Daratumumab in circulation In order to avoid potential side effects of the anti-CD38 therapy on ICI, the infusion of Daratumumab was stopped for 3 weeks prior to the start of the anti-PD1 treatment

For example, this should include time-of-day chronotherapeutic studies that examine whether exogenous melatonin is most beneficial to be given to patients in relation to endogenous rhythms