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Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss

In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]