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In contrast, findings for CDKN2A promotor methylation (encoding p16 INK4A , endogenous CDK inhibitor) are inconsistent [147, 148]

Additionally, EGCGs capacity to modulate mRNA and miRNA expression highlights its potential in regulating gene expression networks that are implicated in cancer progression

They were then spun down at 15,000 g for 45 minutes at 4C and the supernatant was passed over a nickel resin column (Thermo Fisher Scientific, # PI88222) and eluted using buffer B (30mM K2HPO4, 300mM NaCl, 500mM Imidazole, pH 8)

Discussion We established a method, integrating gene co-expression modules in normal human brain with disease-associated genes or SNPs, to identify disease-associated gene co-expression modules that were further used for drug repurposing