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For REU scoring system, lesion severity at each site will be assessed by scoring reticular/hyperkeratotic, erosive/erythematous, and ulcerative lesions using specific criteria: Reticular/hyperkeratotic changes will be rated as 0 (absence of white striations) or 1 (presence of white striations or keratotic papules)

The most significant risk factor is concurrent use of insulin or insulin secretagogues (sulfonylureas like glipizide or glyburide, and meglitinides like repaglinide)

That can cause a potential decrease in oxygen saturation and wake someone from sleep

Thiamine has an important role in mitochondria function and is essential for the function of several enzymes in mitochondria