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Moreover, D-lactate has been shown to be metabolized more readily than initially thought, as confirmed by studies on the half-life of D-lactate in plasma and its excretion in urine after infusion or oral administration 110,111

These inconsistent results also translate to human studies where obesity and steatosis correlated with increased hepatotoxicity after an APAP overdose in some studies [181] and no correlation of toxicity with obesity was observed in other studies [182]