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Description

Up-stream regulators range from classical cytokines (TNF-) and stress pathways (PERK, NF-B) to lysosomal (GLMP), epigenetic (PRMT8) and metabolic (ApoB-100/SORT1) checkpoints, all feeding into a self-propagating loop of iron accumulation, oxidative damage and inflammatory polarization

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Casimir Funk, a scientist from Poland, was the one who first synthesized levodopa in 1911 [37]

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