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As a major form of ketone body, -hydroxybutyrate has been reported to increase TGF- expression in HK-2 renal cells ( TGF- signaling also regulates the metabolism of some structural lipids that define the membrane architecture (Table 1B)

Studies show that interleukin-2-dependent functions including T-cell proliferation, CD8+ T-cell blast generation, cytotoxic T-cell activity, and natural killer cell function are particularly sensitive to glutathione depletion