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There is a lack of consistent data and evidence regarding an optimal use of ALC in treatment of depression

Experience employing dosing regimens from once-a-day to four-times-a-day, as well as studies in primate epilepsy models involving constant rate infusion, indicate that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control and that differences in the ratios of plasma peak to trough concentrations between valproate formulations are inconsequential from a practical clinical standpoint

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

Inflamm Allergy Drug Targets 2013