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Rosety MA, Diaz AJ, Rosety JM, et al

Recent research suggests that alterations in circadian rhythms, particularly in individuals with specific SNPs in clock-related genes like Signal transducer and activator of transcription 3 (STAT3), patatin-like phospholipase domain-containing 3 (PNPLA3), peroxisome proliferator-activated receptor-gamma (PPAR), and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), are linked to NAFLD development and progression [33]

Preclinical research showed that quercetin supports mitophagy and modulates mitochondrial biogenesis, MMP, oxidative respiration, and ATP anabolism as well as intramitochondrial redox status [50]