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Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C et al

These cellular effects are the net result of specific distortions and unwinding in DNA induced by the alkylating or platinating drug and resultant coordinated assembly of distinct proteins at the DNA damage site to activate a number of signal transduction pathways

Moreover, ATRA activates the Nrf2-based pathway, as well as enhances skin resilience to oxidative stress by preventing Nrf2 degradation and modulating genes involved in antioxidant defense, such as SOD and CAT 181

The pyruvate dehydrogenase complex links glycolysis to the citric acid cycle under aerobic conditions