It also makes certain metabolic processes work better
The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite
The following are particularly preferred: Aceton, Methylethylketon, Diethylketon, Methyl-n-butylketon, Methyl-isobutylketon, Cyclohexanon, Cyclopentanon, 2-Methylcyclohexanon, 3-Methylcyclohexanon, 4-Methylcyclohexanon, Dihydroxyaceton, Diacetyl (Monohydrazon), Diacetyl (Dihydrazon), Acetophenon, p-Hydroxyacetophenon, l-Phenylbutan-3-on, Pentan-3-on, Heptan-4-on, Nonan-2-on, Cycloheptanon, Cyclooctanon, Cyclodecanon, Cyclododecanon, Cyclohexanon, 2-Methylcyclohexanon, 3-Methylcyclohexanon, 4-Methylcyclohexanon, Cyclopentanon, 2-Methylcyclopentanon, 3-Methylcyclopentanon, Dimethylketon, Ethylpropylketon, Methylamylketon, Acethylaceton , Pinakolin, Methyl-isopropylketon, Methyl-isoamylketon, Ethylamylketon, Dnsopropylketon, Diisobutylketon, Methyl- vinylketon, Methyl-isopropenylketon, Mesityloxid, Isophoron, Hydroxyaceton, Methoxyaceton, 2,3-Pentandion, 2,3-Hexandion, Phenylaceton, Propiophenon, Benzophenon, Benzoin, Benzil, 4,4'-Dimethoxybenz, 4'-Methoxyacetophenon, 3'- Methoxyacetophenon, O-Ethylbenzoin, (2-Methoxyphenyl)-aceton, (4-Methoxyphenyl)- aceton, Methoxy-2-propanon, Glyoxylsure, Benzylglyoxylat, Benzylaceton,Acetone, methyl ethyl ketone, diethyl ketone, methyl n-butyl ketone, methyl isobutyl ketone, cyclohexanone, cyclopentanone, 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone, dihydroxyacetone, diacetyl (monohydrazone), diacetyl (dihydrazone), acetophenophenophenophenone l-phenylbutan-3-one, pentan-3-one, heptan-4-one, nonan-2-one, cycloheptanone, cyclooctanone, cyclodecanone, cyclododecanone, cyclohexanone, 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone, cyclopentanone, 2-methylcyclopentanone, 3-methylcyclopentanone, dimethyl ketone, ethyl propyl ketone, methyl amyl ketone, acetyl acetone, pinacoline, methyl isopropyl ketone, methyl isoamyl ketone, ethyl amyl ketone, dnsopropyl ketone, diisobutyl ketone, methyl vinyl ketone, methyl isophenyl acetone, hydroxyl, mesophenyl acetone oxyacetone 2 3-pentanedione, 2,3-hexanedione, phenylacetone, propiophenone, benzophenone, benzoin, benzil, 4,4'-dimethoxybenzene, 4'-methoxyacetophenone, 3'-methoxyacetophenone, O-ethylbenzoin, (2-methoxyphenyl) -ac eton, (4-methoxyphenyl) acetone, methoxy-2-propanone, glyoxylic acid, benzylglyoxylate, benzylacetone, Benzylmethylketon, Cyclohexylmethylketon, 2-Decanon, Dicyclohexylketon, Diethylketon, Dnsopropylketon, 3,3-Dimethyl-2-butanon, Isobutylmethylketon, Isopropylmethylketon, 2-Methyl-3-heptanon, 5-Methyl-3-heptanon, 6-Methyl-5-hepten-2-on, 5-Methyl-2-hexanon, 2-Nonaon, 3-Nonaon,5-Nonaon, 2-Octanon, 3-Octanon, 2-Undecanon, 1,3-Dichloraceton, l-Hydroxy-2-butanon, 3-Hydroxy-2-butanon, 4-Hydroxy-4-methyl-2-pentanon, 2-Benzyl methyl ketone, cyclohexyl methyl ketone, 2-decanone, dicyclohexyl ketone, diethyl ketone, dnsopropyl ketone, 3,3-dimethyl-2-butanone, isobutyl methyl ketone, isopropyl methyl ketone, 2-methyl-3-heptanone, 5-methyl-3-heptanone, 6-methyl-5- hepten-2-one, 5-methyl-2-hexanone, 2-nonaon, 3-nonaon, 5-nonaon, 2-octanone, 3-octanone, 2-undecanone, 1,3-dichloroacetone, l-hydroxy-2- butanone, 3-hydroxy-2-butanone, 4-hydroxy-4-methyl-2-pentanone, 2- Adamantanon, Anthron, Bicyclo(3.2.0)hept-2-en-6-on, c/5 , -Bicyclo(3.3.0)octan-3,7-dion, (lS)-(-)-Campher, p-Chloran, Cyclobutanon, Cyclododecanon, 1,3-Cyclohexandion, 1,4-CyclohexandionmonoethylenketaL Dibenzosuberon, Ethyl-4-oxocyclohexancarboxylat, Fluoren-9-on, 1,3-Indandion, Methylcyclohexanon, Phenylcyclohexanon, 4- Propylcyclohexanon, 1,2,3,4-Tetrahydro-l-naphthalinon, l,2,3,4-Tetrahydro-2- naphthalinon, 3,3,5-Trimethylcyclohexanon, 3-Acetoxy-2-cyclohexen-l-on, Benzyhdenaceton, (R)-(-)-Carvon, (S)-(-)-Carvon, Curcumin, 2-Cyclohexen-l-on, 2,3- Diphenyl-2-cylcopropen-l-on, 2-Hydroxy-3-methyl-2-cyclopenten-l-on, Isophoron, - Jonon, -Jonon, 3-Methoxy-2-cyclohexen-l-on, 3-Methyl-2-cyclopenten-l-on, 3-Methyl-3- penten-2-on, Methylvinylketon, (R)-(+)-Pulegon, Tetraphenyl-2,4-cyclopentadien-l-on, 2,6,6-Trimethyl-2-cyclohexen- 1,4-dion, 2-Acetylbenzoesure, 1-Acetylnaphthalin, 2-Acetylnaphthalin, 3'-Aminoacetophenon, 4'-Aminoacetophenon, 4'-cyclohexylaceto- phenon, 3',4'-Diacetoxyacetophenon, DiacetylbenzoL 2',4'-Dihydroxyacetophenon, 2', 5'- Dihydroxyacetophenon, 2 ' , 6 '-Dihydroxyacetophenon, 3 ,4-Dimethoxyacetophenon, 2'-Hydroxyacetophenon, 4'-Hydroxyacetophenon, 3'-Methoxyacetophenon, 4'- Methoxyacetophenon, 2'-Methylacetophenon, 4'-Methylacetophenon, 2'- Nitroacetophenon, 3'-Nitroacetophenon, 4'-Nitroacetophenon, 4'-Phenylacetophenon, 3',4',5'-Trimethoxyacetophenon, 4'-Aminopropiophenon, Benzoylaceton,Adamantanone, Anthrone, Bicyclo (3.2.0) hept-2-en-6-one, c / 5 , -Bicyclo (3.3.0) octane-3,7-dione, (IS) - (-) - camphor, p -Chloran, cyclobutanone, cyclododecanone, 1,3-cyclohexanedione, 1,4-cyclohexanedione monoethylene ketal Dibenzosuberon, ethyl 4-oxocyclohexane carboxylate, fluoren-9-one, 1,3-indanedione, methylcyclohexanone, phenylcyclohexanone, 4-propylcyclohexanone, 1,2, 3,4-tetrahydro-l-naphthalinone, l, 2,3,4-tetrahydro-2-naphthalinone, 3,3,5-trimethylcyclohexanone, 3-acetoxy-2-cyclohexen-l-one, benzyhdenacetone, (R) - (-) - Carvone, (S) - (-) - carvone, curcumin, 2-cyclohexen-l-one, 2,3-diphenyl-2-cyclopropen-l-one, 2-hydroxy-3-methyl-2- cyclopenten-l-one, isophorone, - Jonon, -Jonon, 3-methoxy-2-cyclohexen-l-one, 3-methyl-2-cyclopenten-l-one, 3-methyl-3-penten-2-one, methyl vinyl ketone, (R) - (+ ) -Pulegon, tetraphenyl-2,4-cyclopentadien-l-one, 2,6,6-trimethyl-2-cyclohexen-1,4-dione, 2-acetylbenzoic acid, 1-acetylnaphthalene, 2-acetylnaphthalene, 3'-aminoacetophenone , 4'-aminoacetophenone, 4'-cyclohexylacetophenone, 3 ', 4'-diacetoxyacetophenone, diacetylbenzoL 2', 4'-dihydroxyacetophenone, 2 ', 5'-dihydroxyacetophenone, 2', 6 '-dihydroxyacetophenone, 3, Dimethoxyacetophenone, 2'-hydroxyacetophenone, 4'-hydroxyacetophenone, 3'-methoxyacetophenone, 4'-methoxyacetophenone, 2'-methylacetophenone, 4'-methylacetophenone, 2'-nitroacetophenone, 3'-nitroacetophenone, 4'-nitroacetophenone Phenylacetophenone, 3 ', 4', 5'-trimethoxyacetophenone, 4'-aminopropiophenone, benzoylacetone, Benzoylpropionsure, Benzyhdenacetophenon, Cyclohexylphenylketon, Desoxybenzoin, 4',4'-Dimethoxybenz, l,3-Diphenyl-l,3-propandion, O-Ethylbenzoin, Ethyl-benzoylacetat, Ethyl-(phenylglyoylat), 4'-Hydroxypropiophenon, 1,3-Indandion, 1-Indanon, Isopropylphenylketon, 6-Methoxy- 1,2,3,4-tetrahydro-naphthalin- 1-on, Methyl- phenylglyoxylat, Phenylglyoxylonitr, l-Phenyl-l,2-propandion-2-oxim , Propiophenon, Valerophenon, 2-Acetyl--butyrolacton, 2-AcetylpyrroL l-Benzylpiperidin-4-on, Dehydracetsure, 3,4-Dihydro-4,4-dimethyl-2H-pyran-2-on, l,4-Dihydro-4-pyridinon, N- Ethoxycarbonyl-4-piperidinon, 2-Furylmethylketon, 5-Hydroxy-2-hydroxymethyl-4H- pyran-4-on, 3-Hydroxy-2-methyl-4-pyranon, 3-Indolylmethylketon, Isatin, l-Methyl-4- piperidinon, Methyl-2-pyridylketon, Methyl-3-pyridylketon, Methyl-4-pyridylketon, Methyl- 2-thienylketon, Phenyl-2-pyridylketon, Phenyl-4-pyridyUceton, Tetrahydrofuran-2,4-dion, Tetrahydro-4H-pyran-4-on, 2,2,6,6-Tetramethyl-4-piperidon, Xanthon, Acenaphthenchinon, Brenztraubensure, (lR)-(-)- Campherchinon, (lS)-(+)- Ca pherchinon, 3 , 5.Di-tert-butyl-o-benzochinon, 1 ,2-Dihydroxycyclobuten-3 ,4-dion, Ethyl-(2-amino-4-thiazolyl)-glyoxylat, Ethyl-(phenylglyoxylat), Ethylpyruvat, 2,3- Hexandion, 3,4-Hexandion, 3-Methyl-2-oxo-buttersure,Benzoylpropionic acid, benzyhdenoacetophenone, cyclohexylphenyl ketone, deoxybenzoin, 4 ', 4'-dimethoxybenz, l, 3-diphenyl-l, 3-propanedione, O-ethylbenzoin, ethyl-benzoylacetate, ethyl- (phenylglyoylate), 4'-hydroxypropiophen -Indanedione, 1-indanone, isopropylphenyl ketone, 6-methoxy-1,2,3,4-tetrahydro-naphthalen-1-one, methylphenylglyoxylate, phenylglyoxylonitrile, l-phenyl-l, 2-propanedione-2-oxime, propiophenone , Valerophenone, 2-acetyl--butyrolactone, 2-acetylpyrroL l-benzylpiperidin-4-one, dehydroacetic acid, 3,4-dihydro-4,4-dimethyl-2H-pyran-2-one, l, 4-dihydro- 4-pyridinone, N-ethoxycarbonyl-4-piperidinone, 2-furylmethyl ketone, 5-hydroxy-2-hydroxymethyl-4H-pyran-4-one, 3-hydroxy-2-methyl-4-pyranone, 3-indolylmethyl ketone, isatin, l-methyl-4-piperidinone, methyl-2-pyridyl ketone, methyl 3-pyridyl ketone, methyl 4-pyridyl ketone, methyl 2-thienyl ketone, phenyl 2-pyridyl ketone, phenyl 4-pyridyUcetone, tetrahydrofuran-2,4- dione, tetrahydro-4H-pyran-4-one, 2,2,6,6-tetramethyl-4-piperidone, xanthone, acenaphthenchino n, pyruvic acid, (lR) - (-) - camphorquinone, (lS) - (+) - ca pherquinone, 3, 5.di-tert-butyl-o-benzoquinone, 1, 2-dihydroxycyclobutene-3, 4-dione , Ethyl (2-amino-4-thiazolyl) glyoxylate, ethyl (phenylglyoxylate), ethyl pyruvate, 2,3-hexanedione, 3,4-hexanedione, 3-methyl-2-oxo-butyric acid, 3-Methyl-2-oxo-valeriansure, 4-Methyl-2-oxo-valeriansure, Methyl-phenylglyoxylat, 2-Oxobuttersure, 2,3-Pentandion, 9,10-Phenanthrenchinon, Acetoacetanid, 2-Acetyl-- buttersurelacton, 2-Acetylcyclopentanon, AUyl-acetoacetat, Benzoylaceton, ter- Butylacetoacetat, 1,3-Cyclopentandion, Diethyl-3-oxoglutarat, Dimethyl-acetylsuccinat, Dimethyl-3-oxoglutarat, l,3-Diphenyl-l,3-propandion, Ethyl-acetoacetat, Ethyl- benzoylacetat, Ethyl-butyrylacetat, Ethyl-2-oxocyclohexancarboxylat, Ethyl-2- phenylacetoacetat, Methyl-acetoacetat, 2-Methyl-l,3-cyclohexandion, 2-Methyl-l,3- cyclopentandion, Methyl-isobutyrylacetat, Methyl-3-oxopentanoat, Methylpivaloylacetat, 3-Oxoglutarsure, Tetrahydrofuran-2,4-dion, 2,2,6,6-Tetramethyl- 3,5-heptandion, 3-Benzoylpropionsure, 1,4-Cyclohexandion, Dimethyl-acetylsuccinat, Ethyllvulinat, 2-Aminoanthrachinon, Anthrachinon, p-Benzochinon, 1,4-3-methyl-2-oxo-valeric acid, 4-methyl-2-oxo-valeric acid, methyl-phenylglyoxylate, 2-oxobutyric acid, 2,3-pentanedione, 9,10-phenanthrenequinone, acetoacetanide, 2-acetyl--butyric acid lactone, 2-acetylcyclopentanone, AUyl acetoacetate, benzoylacetone, ter-butylacetoacetate, 1,3-cyclopentanedione, diethyl-3-oxoglutarate, dimethyl-acetylsuccinate, dimethyl-3-oxoglutarate, l, 3-diphenyl-l, 3-propanedione, ethyl acetoacetate, ethyl benzoyl acetate, ethyl butyrylacetate, ethyl 2-oxocyclohexane carboxylate, ethyl 2 phenylacetoacetate, methyl acetoacetate, 2-methyl-l, 3-cyclohexanedione, 2-methyl-l, 3-cyclopentanedione, methyl isobutyrylacetate, methyl 3-oxopentanoate, methylpivaloyl acetate, 3-oxoglutaric acid, tetrahydrofuran-2,4-dione, 2,2,6,6-tetramethyl-3,5-heptanedione, 3-benzoylpropionic acid, 1,4-cyclohexanedione, dimethyl-acetylsuccinate, ethyl levulinate, 2-aminoanthraquinone, anthraquinone, p-benzoquinone, 1,4- Dihydroxyanthrachinon, 1,8-Dihydroxyanthrachinon, 2-Ethylanthrachinon, Methyl-p- benzochinon, 1,4-Naphthochinon, Tetramethyl-p-benzochinon, 2,2-Dimethyl-l,3-dioxan- 4,6-dion, 2-Benzoylbenzoesure, 3-Benzoylpropionsure, 5,6-Dimethoxyphthal- aldehydsure, Glyoxylsure, Lvolinsure, Methyl-(trans-4-oxo-2-pentenoat), Phthalaldehydsure, Terephthalaldehydsure, Dibutylmaleinat, Dibuthylsuccinat,Dihydroxyanthraquinone, 1,8-dihydroxyanthraquinone, 2-ethylanthraquinone, methyl-p-benzoquinone, 1,4-naphthoquinone, tetramethyl-p-benzoquinone, 2,2-dimethyl-l, 3-dioxane-4,6-dione, 2- Benzoylbenzoic acid, 3-benzoylpropionic acid, 5,6-dimethoxyphthalaldehyde acid, glyoxylic acid, levolinic acid, methyl (trans-4-oxo-2-pentenoate), phthalaldehyde acid, terephthalaldehyde acid, dibutyl maleate, dibuthyl succinate, Dibutylphthalat, Dicyclohexylphthalat, Diethyl-acetamidomalonat, Diethyladipat
10.1111/j.1440-1843.2008.01314.x 145
