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Notably, central nervous system (CNS) concentrations often surpass peripheral levels, reflecting impaired efflux of brain-derived MMA across the BBB (Sauer et al

FIGURE 1 The prevalence of DED, which surged to as high as 61.0% during the COVID-19 pandemic (Ji et al., 2023), underscores the influence of increased exposure to visual display terminals and widespread mask usage during the pandemic, which likely exacerbated the condition by decreasing blink frequency and increasing thermal air currents over the ocular area, thus enhancing tear evaporation rates (Uwimana et al., 2022

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