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This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein

The researchers also observed reductions in TNF-, IL-6, total cell counts, neutrophils, MPO activity, and markers of alveolar permeability

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The AhR, a crucial sensor of environmental signals, participates in the DNA damage process through multiple mechanisms upon activation: By directly upregulating the expression of metabolizing enzymes such as cytochrome P450s (CYP1A1, CYP1B1) and aldo-keto reductases (AKRs), AhR promotes the metabolic activation of procarcinogens like polycyclic aromatic hydrocarbons (PAHs) (Shen et al., 2005