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Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss

Abstract Impaired redox metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration and aging

In one of these studies, the patient was female [76] and the authors were able to generate an isogenic control line in parallel to the diseased iPSC line, since X chromosomes are known to undergo random X-inactivation and, hence, monoclonal iPSC lines can be derived from somatic cells with an active healthy or diseased X-chromosome