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This includes its reduction of, but also crosslinking by, benzoquinone, as shown in Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone, as well as the interactions with pyrroloquinoline quinone (PQQ) that is a redox active cofactor for bacterial quinoproteins, which was found to stimulate the redox cycling of TrxR1 with a third quinone, juglone (see Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase)

With the availability of a trxC null mutant, we have also been able to address a number of other questions concerning the disulfidereducing components of the E.coli cytoplasm

10.1186/s40893-016-0012-0 88

The SURMOUNT-1 trial showed that FDA-approved tirzepatide produced average weight loss of 15% at 5mg, 19.5% at 10mg, and 20.9% at 15mg over 72 weeks