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But conversely, the endocytosis and degradation of modified albumin is increased by GP18/GP30 (another membrane-associated albumin binding protein (36), both of which are similarly expressed in heart, liver, spleen and numerous other tissues (35)

Notably, a neutralizing antibody MHM6 inhibited the secretion of TNF- induced by AIMP1 via competing with IgE for binding to CD23, suggesting that the interaction between AIMP1 and CD23 in monocytes might play an important role in autoimmune diseases

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A loss-of-function shRNA targeted screen in metastatic-derived cells identified Gstt1 , a member of the glutathione S -transferase superfamily, as uniquely required for dissemination and metastasis, but dispensable for primary tumour growth