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Recent quercetin co-crystal developments include four new systems: quercetin:caffeine, quercetin:caffeine:methanol, quercetin:isonicotinamide, and quercetin:theobromine dihydrate, each demonstrating superior pharmacokinetic properties (237)

Furthermore, existing studies have not adequately distinguished the relative contributions of transcriptional upregulation of GPX4 versus increased protein stability to the outcomes, leaving some mechanistic explanations still at the inferential level