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Limited information is available regarding use in patients with kidney disease

MiR-155 inhibits the negative regulators of the TLR4 pathway, thereby reducing their expression, promoting macrophage sensitivity to lipopolysaccharide (LPS), and increasing the production of pro-inflammatory TNF in the liver, thus aggravating the inflammatory response [39]

Another important unanswered question concerns the pathophysiological interactions between astrocytes and other glial cells, such as microglia and oligodendrocytes, under neurodegenerative conditions and their associated microenvironments

doi: 10.7759/cureus.50782 160 Committee on Strategies for Responsible Sharing of Clinical TrialDataBoard on Health Sciences PolicyInstitute of Medicine