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They release immunostimulatory signals that can activate dendritic cells, M1-polarized macrophages, and T cells, thereby promoting an antitumor immune response [169]

While no research yet shows a connection to Hashimotos, I wanted to make note that in some cases, individuals may have normal blood levels of folate, but the folate may not be getting to the brain due to autoimmune folate receptor antibodies (FRAs), which block the transport of folate into the cerebral spinal fluid (CSF)

Individuals classed as frail exhibited no difference in non-A/tau neuropathological signatures when compared to the other groups (Lewy body, vascular or TAR DNA binding protein 43 (TDP-43) pathology)