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- acetylcholine will produce a dose-dependent changes of blood pressure & heart rate (Figure 1)(Vanderah, 2024): : Low-dose intravenous acetylcholine Primarily activates muscarinic (M3) receptors on vascular endothelial cells (Gericke et al, 2011)

Zimmerman, J

Lassen, M

This paper demonstrates a molecular mechanism for direct sensing of physiological ROS at the TOM complex, mediated through the TOM20-bound E3 ligase FEM1B