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In Alzheimers models, metformin has been shown to reduce amyloid- deposition, inhibit tau hyperphosphorylation, and improve synaptic integrity [172]

eLife 11 , e78609 (2022)

Yes, supplementation with amino acids such as arginine, lysine, ornithine, and glycine can stimulate HGH secretion, which may increase IGF-1 production