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Unlike classical neurotransmitters, its not definitively produced within neurons, lacks confirmed precursor molecules in neural tissue, and has no conclusively demonstrated direct receptor binding

NAD, a coenzyme found in every cell, supports energy production at a cellular level and can be taken via infusion or a self-administered injector pen

The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)

Jaypirca is specifically intended for adults who have undergone at least two prior lines of therapy, including another BTK inhibitor and a BCL-2 inhibitor