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One of the problems that influences the therapeutic efficacy of stem cell therapy is cell survival due to oxidative and inflammatory stress

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Functional impairment of coronary microvascular function may be triggered by low-grade systemic inflammation [19, 20], reduction of nitric oxide (NO) bioavailability, increased levels of vasoconstriction mediators [21], increased oxidative stress, increased leukocyte infiltration, neurohormonal activation, microvascular wall barrier dysfunction and altered vascular endothelial permeability [22]

The incidence of CRC was inversely associated with vitamin B6 intake and blood PLP levels (131)