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These challenges include the actions of immunosuppressive cells and molecules in the TME, inferior durability of CAR T cell expansion in vitro, and barriers to CAR T-cell infiltration and transport to tumor locations

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However, we are not ignoring the fact that chromosomally encoded copper efflux systems have been detected in this bacterium, which could infer the possibility of chromosomal silver resistance due to the similarities between copper and silver efflux mechanisms (Williams et al., 2016

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