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Further, in cultured cells, manipulation of GPx-1 expression specifically alters the rate of UV-induced mutagenesis

Bile acids have cytotoxic effects that activate HSCs and stimulate the secretion of profibrogenic mediators, such as transforming growth factor beta, reactive oxygen species, TNF-, and platelet-derived growth factor (Waisbourd-Zinman et al., 2016)

Acknowledgments The authors thank all the doctors at the National Taiwan University Veterinary Hospital for their assistance with case and sample collection