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The rapid clearance of these microvesicles occurs most likely by Kupfer cells and other macrophages via recognition of exposed PS, as established in an animal model using rats (Willekens et al., 2005)

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Pediatrics 109:150152 Scaglia F, Brunetti-Pierri N, Kleppe S et al (2004) Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism