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THP-1 (ATCC TIB-202) cells were cultured in RPMI 1640 (PAN-biotech) supplemented with 10% FBS and 1% antibiotic/antimycotic

Acute moderate-intensity training increased total immunoglobulin E (IgE) levels in allergic rhinitis patients ( Regular moderate-intensity exercise also increases salivary secretory IgA (SIgA) in older adults ( + B-cell counts and factors related to IgA synthesis, thus strengthening intestinal IgA production and immune function ( 3.1.6 Effects on cytokines Moderate-intensity exercise exerts a wide range of effects on cytokines, especially in the modulation of critical cytokines like IL-6, TNF-, and IL-10.The release of IL-6 from contracting skeletal muscle, first identified as a myokine nearly two decades ago, represents a hallmark cytokine response to endurance exercise

Older people are also at risk because they are more likely to have problems absorbing B12

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